Dehydrooligopeptides. XI. Facile syntheses of various kinds of dehydrodi- and tripeptides, and dehydroenkephalins containing .DELTA.Tyr residue by using N-carboxydehydrotyrosine anhydride.
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概要
- 論文の詳細を見る
Several kinds of <I>N</I>-free and protected <I>N</I>-carboxydehydrotyrosine anhydride (<I>Δ</I>Tyr·NCA) derivatives, derived by both the cyclization of the corresponding <I>N</I>-benzyloxycarbonyldehydrotyrosine derivatives and the protection of the resulting <I>Δ</I>NCA, were employed for a one-pot dehydrooligopeptide (DHP) synthesis. As a result, various kinds of DHPs with a wide variety of combinations of sequences could be synthesized in fairly good yields. In addition, by utilizing the obtained information, two kinds of leucine-dehydroenkephalins containing a <I>Δ</I>Tyr<SUP>1</SUP> and both <I>Δ</I>Tyr<SUP>1</SUP> and <I>Δ</I>Phe<SUP>4</SUP> residues were also synthesized.
- 公益社団法人 日本化学会の論文
著者
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Shin Chung-gi
Laboratory Of Oraganic Chemistry Faculty Of Engineering Kanagawa University
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Yonezawa Yasuchika
Laboratory Of Oraganic Chemistry Faculty Of Engineering Kanagawa University
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Obara Takumi
Laboratory of Organic Chemistry, Faculty of Technology, Kanagawa University
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Taniguchi Shuji
Laboratory of Organic Chemistry, Faculty of Technology, Kanagawa University
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