Convenient Syntheses of 3-Deoxy-D-manno-2-octulosonic Acid (KDO) and 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid (KDN) Derivatives from D-Mannose

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概要

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• Horner-Wittig reactions of 4-O-benzyl-2,3:5,6-di-O-isopropylidene-D-mannose and 2,3,4,5,6,7-hexa-O-benzyl-6-D-glycero-2,3,4,5-D-galacto-heptose with methyl 2-benzyloxycarbonylamino-2-(diethoxyphosphoryl)acetate gave the corresponding α-dehydroamino acid derivatives in good yields, respectively. They were converted to methyl 3-deoxy-4,5:7,8-di-O-isopropylidene-α-D-manno-2-octulopyranosonate and methyl (methyl 3-deoxy-D-glycero-β-D-galacto-2-nonulopyranosid)onate via methyl α-oxoalkanoate derivatives.

• 日本化学会の論文
• 1994-01-05

著者

• SATO Ken-ichi

  Laboratory of Molecular Biology, Biosignal Research Center, Kobe University

• Yonezawa Yasuchika

  Laboratory of Organic Chemistry, Faculty of Technology, Kanagawa University

• Miyata Tomoyuki

  Laboratory Of Organic Chemistry Faculty Of Engineering Kanagawa University

• TANAI Ikuo

  Laboratory of Organic Chemistry, Faculty of Engineering, Kanagawa University

• Tanai Ikuo

  Laboratory Of Organic Chemistry Faculty Of Engineering Kanagawa University

• Yonezawa Yasuchika

  Laboratory Of Organic Chemistry Faculty Of Engineering Kanagawa University

• Yonezawa Yasuchika

  Laboratory Of Oraganic Chemistry Faculty Of Engineering Kanagawa University

• 佐藤 憲一

  Laboratory of Organic Chemistry, Faculty of Engineering, Kanagawa University

• Tanal Ikuo

  Laboratory of Organic Chemistry, Faculty of Engineering, Kanagawa University

• Sato Ken-ichi

  Laboratory of Chemistry for Natural Products, Faculty of Science, Tokyo Institute of Technology

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