.ALPHA.,.BETA.-Unsaturated carboxylic acid derivatives. XVII. The facile synthesis of ethyl .ALPHA.-azido-.ALPHA.-alkenoates and reduction to ethyl .ALPHA.-amino-.ALPHA.-alkenoates.
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概要
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Several pathways leading to ethyl α-azido-α-alkenoates (<B>8</B>) by the β-elimination to ethyl α-azido-β-substituted (hydroxy-, acetoxy-, or mesyloxy)-alkanoates with NaN<SUB>3</SUB> or Et<SUB>3</SUB>N have been examined. The optimized procedure, in combination with subsequent reduction provides a general synthetic route to α-amino-α-alkenoic acid esters (<B>9</B>). The configuration of <B>8</B> and <B>9</B> have been shown to be of (<I>Z</I>)-geometry.
- 公益社団法人 日本化学会の論文
著者
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Shin Chung-gi
Laboratory Of Oraganic Chemistry Faculty Of Engineering Kanagawa University
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Yonezawa Yasuchika
Laboratory Of Oraganic Chemistry Faculty Of Engineering Kanagawa University
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Yoshimura Juji
Laboratorium für Organische Chemie Technische Hochschule Tokyo
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Unoki Kazuo
Laboratory of Organic Chemistry, Faculty of Technology, Kanagawa University
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Shin Chung-gi
Laboratory of Chemistry for Natural Products, Faculty of Science, Tokyo Institute of Technology
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