.ALPHA.,.BETA.-Unsaturated carboxylic acid derivatives. XII. A convenient synthesis of oxazole-4-carboxylic and 3,3-dibromo-2,2-diamino acids.

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概要

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• Treatment of <I>t</I>-butyl 2-acetylamino-3-bromo-2-alkenoate with triethylamine gave <I>t</I>-butyl 5-alkyl-2-methyloxazole-4-carboxylate by dehydrobromination, but no reaction occurred with primary amines. While treatment of <I>t</I>-butyl 2-acetylimino-3,3-dibromoalkanoate with hydroxylamine or several aliphatic and aromatic primary amines gave addition products, <I>t</I>-butyl 2-acetylamino-3,3-dibromo-2-(hydroxyamino)- and 2-(substituted amino)alkanoate, respectively, in fairly good yields.

• 公益社団法人 日本化学会の論文

著者

• Yoshimura Juji

  Laboratorium für Organische Chemie Technische Hochschule Tokyo

• Sugiyama Hidetoshi

  Laboratory of Organic Chemistry, Faculty of Technology, Kanagawa University

• Sato Yoshiaki

  Laboratory of Organic Chemistry, Faculty of Technology, Kanagawa University

• Shin Chung-gi

  Laboratory of Chemistry for Natural Products, Faculty of Science, Tokyo Institute of Technology

• Nanjo Katsumi

  Laboratory of Organic Chemistry, Faculty of Technology, Kanagawa University

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