53. 脳血管攣縮による脳虚血に対する人工血液 Fluosol-DA, 20%の効果

概要

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Fluosol-DA, 20% is a newly developed perfluorochemical emulsion and proved to be effective on the experimental cerebral ischemia. A total of 51 administrations of the solution was performed in 24 patients suffering from symptomatic cerebral vasospasm due to ruptured aneurysms. Their neurological conditions were evaluated before and after the intravenous infusion.<BR>Fifteen cases (62%) out of twenty four (25/51 times of administration) showed improvement of disturbed consciousness and/or motor weakness which continued for about 24 hours after the administration. The cases with anterior communicating artery aneurysms had better improvement ratio (10/11 cases, 16/24 times than those with aneurysms located in the other regions (5/13 cases, 9/27 times). The solution was considered to be more effective to improve motor weakness (13/27 times) than disturbed consciousness (18/49 times). In some cases, marked increase of cerebral blood flow or appearance of a wave on EEG was observed in accordance with the improvement of the condition.<BR>From these clinical data, Fluosol-DA, 20% is considered to be one of the effective treatments to improve cerebral ischemia due to vasospasm.
The Japanese Society on Surgery for Cerebral Strokeの論文