いわゆる非機能性下垂体腺腫における α subunit陽性細胞について

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Operative specimens of 73 pituitary adenoma cases (25 cases of prolactinoma, 24 cases of acromegaly, 21 cases of non-functioning adenoma, and 3 cases of gonadotropin secreting adenoma) were examined immunohistochemically for luteinizing hormone (LH) β subunit, follicle stimulating hormone (FSH) a subunit, FSH β subunit, and thyroid stimulating hormone (TSH) by using the peroxidase antiperoxidase method. Four cases of prolactinoma were positive for the FSH α subunit. Nineteen cases of acromegaly were positive for the FSH α subunit. These cases were also positive for the FSH β and/or LH β subunit. In gonadotropin secreting adenoma all 3 were positive for both FSH α and β subunits. Eleven cases of non-functioning adenoma were positive for the FSH α subunit. Six of 11 (3 male and 3 female) were positive only for FSH α subunit. A high serum human chorionic gonadotropin α subunit value was recognized in 1 case of these 6. In an endocrinological study of non-functioning adenoma cases of positive FSH α subunit low response of TSH to TSH-releasing hormone loading and low response of LH to LH-releasing hormone (LH-RH) loading were found. However, this abnormal response was not statistically significant. In FSH response to LH-RH loading 1 case had delayed response and 7 cases had low response. This abnormal FSH response to LH-RH was statistically significant in 9 FSH α subunit positive cases. These data indicate that there are α subunit secreting pituitary adenomas in the group which has been diagnosed as "non-functioning adenoma".
日本脳神経外科学会の論文
1985-05-15

いわゆる非機能性下垂体腺腫における α subunit陽性細胞について

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