糖負荷における血中amylaseの変動について

概要

論文の詳細を見る
In about half the investigated cases, serum amylase level fell below 90 % of the pretreatment value when it was measured during oral and intravenous glucose tolerance test in man. A negative correlation was obtained between the rate of increase of serum glucose level and that of decrease in serum amylase value. In rats, the serum amylase level was decreased after intravenous carbohydrate administration, among which glucose showed the greatest effect and fructose had no effect at all. This result suggested that aldehydes might play some role in the mechanism of the decreased amylase level in serum as compared to the function of ketose. This was shown to be likely by the observation that intravenously injected acetaldehyde and glyceraldehyde decreased serum amylase levels. On the other hand, the amylase value was not influenced by insulin, glucagon or adrenalin administration. In partially hepatectomized rats, amylase level was unchanged after carbohydrate injection. It was thus concluded that the liver plays a role in regulation of serum amylase level.
学校法人昭和大学・昭和医学会の論文