Systemic lupus erythematosus(SLE)にthrombotic thrombocytopenic purpura(TTP)を合併した1症例

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Systemic lupus erythematosus (SLE), complicated by thrombotic thrombocytopenic purpura (TTP), has been reported in only 12 individual cases in Japan until 1979. We experiencel a case of SLE accompanied by TTP in a 23-year-old woman. The patient complained of arthralgia and was diagnosed as SLE, because of arthritis without deformity, LE cell, proteinuria, granular casts in urine, neuropsychic manifestation, leucopenia and thrombocytopenia. During 4 years, she repeated the admission of hospital 4.times. She died of renal failure after showing watery diarrhea and psychic manifestation. In autopsy, onion-skin lesions in the spleen and wire-loop lesions in the glomeruli were observed. In the kidneys, lungs and pancreas, there were multiple microthrombi in small blood vessels. We diagnosed this case as SLE complicated by TTP.
学校法人昭和大学・昭和医学会の論文