慢性膵炎における膵液hexosamineの臨床的意義

概要

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The clinical picture of alcoholic pancreatitis is more critical than that of other forms of chronic pancreatitis. This study was undertaken to investigate the pathophysiology of the alcoholic pancreatitis. Mucoprotein in the pancreatic juice, using hexosamine determination, was measured after the analytical method was evaluated. In order to exclude any false positive result, commonly found in biliary diseases, the 4th post-secretin fraction for hexosamine determination in pancreatic diseases was used. It was found that the hexosamine concentration was high in chronic pancreatitis, especially in alcoholic chronic pancreatitis. The hexosamine value correlated well with the degree of the functional disorder of the pancreas. Hexosamine concentration was significantly higher in alcoholic chronic pancreatitis when it was compared with the other forms of chronic pancreatitis with the same degree of pancreatic disorders. From these results, it seems that the mechanism of the onset or development of alcoholic chronic pancreatitis seems to be specific and that the mechanism is closely related to the production of mucoprotein.
学校法人昭和大学・昭和医学会の論文