重症急性膵炎死因の解析

概要

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Twenty five cases of acute pancreatitis, of which 18 survived, are discussed and compared with other reports on pathogenesis, pathophysiology and the severity index of fatal pancreatitis. Fatal pancreatitis was likely to occur in cases of the disease which are accompanied by gallstones, and the prognosis for patients over 50 years of age has been poor. The most important clinical findings on the severity index were shock and renal failure and, although the specific laboratory markers were not decided, decreases of serum Ca and platelet and increases in BUN were suggested. Pathologically, the pancreas showed hemorrhagic necrosis and the kidney, cloudy edema and tubular necrosis. From the above results, we speculated that if the severity of pancreatitis were determined early enough and, thus, appropriate treatment for circulatory failure and renal injury applied, more patients might be saved.
学校法人昭和大学・昭和医学会の論文