ラット下顎頭関節軟骨線維層の微細構造と細胞分裂能に関する実験的研究

概要

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Three week-old and 6 week-old rats were given intraperitoneal injections of colchicine in a 0.05 percent saline solution, the dosage was 1 mg/kg body-weight. Accumulation of arrested metaphases in the fibrous zone of the mandibular condyle could be observed. Light microscope study of the plastic-embedded semithin sections of mandibular condyle identified two layers (F1 layer and F2 layer) in the fibrous zone. In these two layers age related changes of the tissue structure were obserbed. It is shown that the fibroblast-like cells in F1 and F2 layers have mitotic division ability as old as 6 weeks of age, and that the F1 layer tended to disapper before 6 weeks, while the F2 layer became thicker because of a conspicuous formation of thick bundles of collagen fibers in the matrix.