Inhibitory action of galanin on insulin secretion. Effects on basal and glucose-stimulated secretion of insulin.:Effects on basal and glucose stimulated secretion of insulin

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Action of galanin on insulin and pancreatic glucagon secretion was investigated with synthetic galanin at the basal and stimulated secretion by low-dose glucose infusion.1) Galanin infusion caused rapid and reversible inhibition of the basal insulin secretion in a dose-dependent manner. Plasma glucose levels gradually increased by galanin administration with dose-dependency, and the maximal hyperglycemic action was observed when galanin was infused at a rate of 4μg/kg/hr. Cortisol, growth hormone, adrenalin or noradrenalin, which was considered to contribute to the plasma glucose regulation, was not affected by galanin infusion.2) During continuous infusion of low-dose glucose, galanin caused no significant changes in plasma glucose levels at a rate of 4μg/kg/hr. Infused at a rate of 16μg/kg/hr, galanin caused significant hyperglycemia similar to that seen at 4μg/kg/hr in the basal secretion.3) Pancreatic glucagon levels were not affected by galanin administration both at the basal state and duing low-dose glucose infusion.These results indicate that galanin may play a role in the plasma glucose regulation through the inhitory action on the basal insulin secretion.
財団法人日本消化器病学会の論文