Experimental study on splanchnic circulation by ultrasonic transit time volume flow meter and laser Doppler flow meter.

概要

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Both measurement of blood flows in superior mesenteric artery and portal vein by newly developed ultrasonic transit time volume flow meter and measurement of blood flow in pancreatic tissue by laser Doppler flow meter, were performed simultaneously and continuously in dogs. By this system, the effect of VIP and Neuromedin N, a newly identified neurotensin-like peptide, was investigated. VIP induced much increse of blood flow in pancreatic tissue but relatively less increase in superior mesenteric artery, whereas neuromedin N induced most remarkable increase in superior mesenteric artery. The effects of these peptides on splanchnic blood flows were clearly characterized by this measurement system. Ultrasonic volume flow meter was also useful for the measurement of splanchnic blood flow in a conscious dog. These flow meters were found to be very helpful for further gastrointestinal investigations because of their stable, continuous and real-time measurement.