Effect of gastrin-releasing peptide on pancreas. II Effects of GRP on pancreatic, intestinal, gastric and femoral arterial blood flow.:II. Effects of GRP on Pancreatic, Intestinal, Gastric and Femoral Arterial Blood Flow

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Effects of synthetic porcine gastrin-releasing peptide (pGRP) on pancreatic, intestinal, gastric and femoral arterial blood flow in anesthetized rabbits were compared with those of cholecystokinin-octapeptide (CCK-8). Blood flow was measured with electromagnetic flowmeter. pGRP (0.5, 2μg/kg. I.V.) significantly and dose-dependently increased pancreatic blood flow. However, gastric and intestinal blood flows showed mild biphasic changes consisting of transient decrease followed by gradual increase in response to pGRP. Femoral arterial blood flow decreased significantly. Both CCK-8 and pGRP increased pancreatic blood flow remarkably. However, intestinal blood flow also increased markedly in response to CCK-8. Femoral arterial blood flow decreased significantly. These differences between the responses of intestinal blood flow to pGRP and CCK-8 suggest that hemodynamic effect of pGRP is not mediated by CCK. Furthermore, the effect of pGRP on pancreatic blood flow was not affected by total resection of small intestine, performed to exclude the influence of intrinsic CCK. Therefore, it appears that pGRP has a direct stimulatory effect on pancreatic blood flow, corresponding to the pancreatic enzyme secretion, without the mediation of the release of CCK.
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