レーザードップラー法による犬膵血流量の測定-消化管ホルモン (vip, phi, grp) に対する反応-

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In this study, canine pancreatic blood flow was measured by Laser Doppler Flowmetry, which is a new technique for monitoring capillary perfusion. This technique is sensitive, resproducible and noninvasive, and allows continuous measurement of pancreatic blood flow.The effects of gut hormones (VIP, PHI, and GRP) were also examined by using this technique. Intravenous injection of either VIP or PHI increased pancreatic blood flow in a dose-related manner. VIP was, however, much more potent than PHI. Intravenous bolus injection of GRP induced a biphasic response of blood flow with an initial reduction followed by a small gradual increase, whereas continuous infusion of GRP caused a marked reduction of blood flow. These results suggest that Laser Doppler Flowmetry is useful not only for studying the effects of gut hormones on pancreatic blood flow but also for investigating the hemodynamics of the pancreas for various other purposes.
財団法人日本消化器病学会の論文