:I. Effect of VIP on Normal Pancreas

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Two methods were used for measurement of the normal pancreatic tissue blood flow in dogs: a hydrogen gas clearance method and a thermoelectric method.The basal blood flow in both the right and the left lobes of the pancreas could be measured simultaneously by the hydrogen gas clearance method, and no significant difference was found between the basal blood flow of the right and the left lobe.After we examined the reproducibility and reliability of the thermoelectric method, changes in the pancreatic tissue blood flow in response to VIP were measured continuously by this method. Prompt and significant increases were induced by both synthetic chicken and porcine VIP and no significant difference was observed between the effect of synthetic chicken and porcine VIP in this biological action. However, synthetic chicken VIP was weaker than synthetic porcine VIP in lowering systemic arterial pressure.Synthetic chicken VIP stimulated increases in exocrine pancreatic and biliary secretions and in portal insulin and glucose levels. The present study suggests that the stimulatory effects of VIP on endocrine and exocrine functions of the pancreas are closely related to the increased pancreatic blood flow elicited by VIP.
財団法人日本消化器病学会の論文