Effect of gastrin-releasing peptide on pancreas. I. Stimulatory mechanism of pancreatic exocrine secretion.:I Stimulatory Mechanism of Pancreatic Exocrine Secretion

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This study was conducted to clarify whether synthetic porcine gastrin-releasing peptide (pGRP) can stimulate pancreatic exocrine secretion and whether the effect is direct or CCK-mediated in rabbits. pGRP infused intravenously in anesthetized rabbits with pyloric ligation elicited a potent increase in pancreatic protein and enzyme secretion without a significant change in juice flow and bicarbonate secretion. The protein and enzyme response was correlated with the dose of pGRP from 0.1 to 2mcg/kg-hr. The effect of pGRP on pancreatic secretion was not affected by either the resection of the small intestine to exclude CCK or the resection of the small intestine with a truncal vagotomy. Furthermore, the in vitro study showed that pGRP in KHB solution significantly stimulated the liberation of amylase and lipase from the pancreatic tissue. Therefore, it was suggested that pGRP had a potent and direct stimulatory effect on pancreatic enxyme secretion without the mediation of CCK.
財団法人日本消化器病学会の論文