Inhibition of meal-stimulated gastrin release by intrajejunal acidification in conscious dogs.

概要

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This study was conducted to investigate the ability of the jejunum to inhibit the release of gastrin, associated with the inflow of gastric acid into the jejunum, using beagle dogs with jejunal loop fistula and end-to-side jejuno-ileal anastomosis. Dogs were fed a protein meal to stimulate gastrin release, followed 15 minutes later by intrajejunal infusion of 0.1 N HCl solution at a rate of 3.1ml/min for 15 minutes through the jejunal fistula. Plasma gastrin, secretin and VIP levels were observed.Postprandial elevation of the gastrin level during the intrajejunal HCl infusion was less than that in control experiment without HCl infusion, and incremental integrated response of gastrin after feeding was significantly inhibited by HCl infusion. Plasma secretin and VIP levels rose significantly by HCl infusion, and fell after terminating the infusion. These results suggest that the jejunum, similar to the duodenum, is latently able to inhibit gastrin release mediated mainly by secretin and VIP release associated with the inflow of gastric acid.
財団法人日本消化器病学会の論文