SLEと膵病変-膵実質残存率からの障害程度の検討-

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The present study was undertaken to determine the degree of pancreatic injury in 18 patients with SLE 27 autopsy cases. Of the 18 patients there were 7 cases (33%) with clinical symptoms of pancreatitis such as abdominal pain or hyperamylasemia including one case (6%) with obvious complications of acute pancreatitis, and two cases (11%) showing a definite decline in the pancreatic exocaline function test.Microscopic examinations of the pancreas in the 27 autopsy cases revealed 20 lesions; 2 arteritis (7.4%), 10 thrombosis (37.0%) 6 focal pancreatitis (22.2%), 8 periductal fibrosis (29.0%), 11 interlobular fibrosis (40.7%), 6 ductule dilatation (22.2%), and 7 fat diposition (25.9%).The rate of residual volume of the pancreas parenchyma, estimated by the point counting method was 79.2% in SLE, and 82.9% in control subjects. Although the difference was insignificant, six cases of SLE decreaed. The lowest value was 63% which was higher than the highest value of the moderate disturbance group of chronic pancreatitis. The cause for the decrease in the residual volume was considered to be independent of any specific lesion, but associated with the numbers of the lesions.These findings suggest that pancreatic demage in SLE are generally mild and occure more frequently than commonly accepted, but such severe pancreas damage as chronic pancreatitis might be rare.
財団法人日本消化器病学会の論文