先天性胆道閉鎖症における肝内増殖胆管上皮のレクチンに対する結合特性の検討

概要

論文の詳細を見る
Histopathological condition of intrahepatic bile ducts with special reference to lectin binding capability were examined on liver in 13 cases of biliary atresia (BA). Seven types of FITC labeled or biotinylated lectin were used in this study. Among of them, Helix Pomatia Agglutinin (HPA) only showed characteristic binding pattern to bile duct epithelium. HPA binding capability with negative Alcian-Blue staining of the bile duct epithelium was normally seen only in the fetus and infants younger than one month of age. In cases of BA, HPA positive epithelium of the proliferative bile ducts were observed until 5 months of age in the central portion of the portal triad. Results of this study strongly suggested that persistence of fetal charactericity of the bile duct in BA patients remains several months longer than in normal infants.
日本小児外科学会の論文
1987-12-20