先天性胆道閉塞症 (CBA) の肝外索状胆管における炎症性細胞浸潤の動態

概要

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Infiltrating pattern of Inflammatory cells in the extrahepatic bile duct of biliary atresia (BA) was examined immunohistochemically. Specimens were obtained from 7 cases at the time of radical opera-tion. The monoclonal antibodies used in this study were T4 (CD4), T8 (CD8), Leu-15 (CD11), MY4 (CD14#), M1 (CD15), ILR2 (HLA D/DR) and IL-1. The infiltrating pattern of inflammatory cells were divided into two groups according to cell number infiltrated. In one group, most of cells were com-posed by T4^+ (helper/inducer T) cells and T8^+, Leu-15^- (Cytotoxic T) cells and, in some cases, Leu-M1^+ cells were also observed. But B1^+ (B) cells were hardly detected in this area except for lymph follicle. In the other group of less numbers of cells, bile ducts were enclosed by mature fibrous tissues and only MY4^+ cells were left as scavenger. As for regional differences, hepatic hilus showed more severe inflammatory features comparing to other portions of the extrahepatic bile duct. Postoperative bile flow in patients with rich inflammatory cells were more active than that of patients with scanty inflammatory cells. Therefore, it might be concluded that the radical operation for BA should be performed before the acute inflammatory process subsides.
日本小児外科学会の論文
1988-10-20