Endotoxemia in various liver diseases and gram-negative septicemia using limulus coloric test (LCT)

概要

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Using Toxicolor, commercially available kit for the quantitative measurement of endotoxin in the blood, endotoxemia was investigated on various liver diseases and gram-negative septicemia. Toxicolor proved itself to yield nearly 90% of recovery of endotoxin acitivity from plasmas of normal controls and patients. Moreover, its recovery was not influenced by the bilirubin level of the plasmas. In cirrhotic patients, hitherto reportedly having high positive rate of endotoxemia, decompensated cases with ascites only showed endotoxemia with positive rate of 44% and its maximum level of 39pg/ml, a hundredth order of previous reports. In patients with hepatocellular carcinoma, endotoxemia was only present in hepatic failure. In gram-negative septicemia, endotoxin was detected in all cases. Disseminated intravascular coagulation (DIC) complicated the endotoxemia at relatively high concentration, above 50pg/ml.