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We investigated the effect of prostaglandin F2α (PGF2α) on gastric emptying, small bowel transit time (SBTT), gut hormone release and blood glucose in 8 normal subjects. After an overnight fast, PGF2α at the concentrations of 0.25, 0.50, 0.75μg/kg/min was administered intravenously for 60min. PGF2α caused a dose-dependent acceleration of SBTT with a simultaneous dose-related increase of plasma gut GLI and blood glucose. Negative correlations were observed between the integrated incremental response of gut GLI or that of blood glucose for 120min after PGF2α or saline infusion and SBTT. Gastric emptying, plasma gastrin concentration and plasma motilin concentration did not change significantly during PGF2α infusion. These results raise the possibility that PGF2α causes the acceleration of SBTT directly, not by the increase of motilin release, and that an acceleration of SBTT causes the increase of absorption of glucose and the subsequent increase of blood glucose which may be responsible for the increase of gut GLI.
財団法人日本消化器病学会の論文