Studies on the Lymphocyte Transformation Induced by Stimulation with Liver Nuclear Membrane Fractions in thePatients with Liver Disease

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Lymphocyte transformation induced by the stimulation with nuclear membrane fractionsof rat liver was studied using a microvolume peripheral blood cultures obtained from patientswith liver disease. Although no responses were seen in healthy controls, positive responseswere frequently observed in patients with liver disease: 43% in acute hepatitis, 35% inchronic inactive hepatitis, 86% in chronic active hepatitis, 30% in liver cirrhosis and 14% inhepatoma.Many cases which had shown the positive response to the nuclear membrane fractionswere also revealed the positive response against the HBs-antigen, while those of negative caseswere less responsible to the HBs-antigen.Also, correlation between the responsiveness of lymphocytes to the liver specific antigenand to the nuclear membrane fractions was high in patients with liver diseases.
財団法人日本消化器病学会の論文