喫煙刺激による気道反応のボディプレチスモグラフ法とオシレ-ション法の検出力比較

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Two pulmonary function tests-whole body plethysmography and the forced oscillation method-were used to determine the degree of constriction of human airway passages induced by irritant aerosols. Cigarette smoke particles were employed as an irritant. Nine healthy male smokers were asked to inhale cigarette smoke deeply 15 times over a 5-minute period. Pulmonary functions-airway resistance (Raw), specific airway conductance (s-Gaw) and, magnitude of respiratory impedance (|Z|) and respiratory resistance (Rrs)-were measured before and after smoking both by plethysmography and by the oscillation method.After smoking, the values of Raw and s-Gaw changed significantly (p<0.05), indicating that constriction of airway passages had occurred, and a significant increase in the values of |Z| and Rrs were also observed.The data indicate that the forced oscillation method was as sensitive as whole body plethysmography in detecting changes in the airway caliber by smoking. The frequency dependence of the values of Rrs suggests that for several subjects, cigarette smoking may cause acute effects in the small peripheral airway as well.
日本衛生学会の論文