NO_2, O_3および両者の混合ガスの吸入による気道反応

概要

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One hour inhalation of 0.7 ppm (1.32 mg/m^3) of nitrogen dioxide (NO_2), 0.7 ppm (1.4 mg/m^3) of ozone (O_3), and their mixture, 0.5 ppm (0.9 mg/m^3) of NO_2 and 0.5 ppm (1.0 mg/m^3) of O_3, and sham inhalation were conducted in five healthy male volunteers through mouth breathing using a multipurpose inhalation apparatus. Airway response was measured by specific airway conductance (Gaw/Vtg) and maximum expiratory flow rate at 50 and 25 percent forced vital capacity (V_<max50>, V_<max25>). Evaluations by analysis of variance revealed: no significant effect in inhalation of NO_2 alone, slight significant transient decrease of V_<max50> in inhalation of O_3 alone (0.1>p>0.05), and slight reversible decrease of Gaw/Vtg and V_<max50> in halation of NO_2 and O_3 combination (0.1>p>0.05). As their variations were within the range of normal diurnal change, these results were considered to be non-adverse effects.
社団法人日本産業衛生学会の論文
1981-05-20