疎水性Aerosols (Triphenyl phosphate粒子)の気道内沈着に関する研究

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The nonhygroscopic aerosol deposition in the human respiratory tracts according to its particle size was examined by reinhalation method.The method of the experiment and the results are as follows:Triphenyl phosphate aerosols (diameter ranges: 0.24μ-3.2μ, S.D.: 0.6μ) was generated to stock into a large Tisseau spirometer by Lauterbach generator. The breathing was performed by 2 healthy human subjects (one male and one female). The inhaled air from the stock spirometer was exhaled to collect into the first Benedict-Roth type spirometer. The air was reinhaled and the exhaled air was collected into the second spirometer. In the same way the last exhaled air was collected into the third spirometer. The rates of respiration used were 10, 15 and 60 per minute and 7 series of the experiment were made. The aerosols were sampled from each spirometer by thermal precipitator, and their frequency distribution, number median diameter (N.M.D.) and standard deviation were determined photomicroscopically.The total respiratory deposition was estimated to ca 90%, by calculation of the T.P.P. aerosol counts of the samples from the 4 spirometers. No significant change in the deposition rate was found in the different respiration rate. As has been reported by many investigators, the larger the particle diameter, the more the percent of deposition. The N.M.D. of the aerosols in the lastly expired air decreased 0.16μ-0.56μ and its S.D. 0.2μ from the preexperimental values. The total respiratory tract deposition versus particle diameters showed considerable variations among individuals. However, in the vicinity of diameter 0.48μ, a fairly uniform deposition rate, ca. 75%, was found in all cases. This fraction of diameter coincides with Landahls theoretical minimum deposition size 0.4μ.
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疎水性Aerosols (Triphenyl phosphate粒子)の気道内沈着に関する研究

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