一酸化炭素一回曝露の学習行動影響にみられる性差

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Sex difference of effects of single exposure of carbon monoxide (CO) on operant behavior was studied in adult rats. The animals were obtained by continued selective breeding and have a high level of avoidance ability and small individual differences (THA rat: Tokai high avoider rat). Experiments were conducted as follows: Exposure were carried out at the concentrations of 50, 100, 200 and 400ppm of CO gas for 4h in THA rats, and their operant behavior was studied by Sidman avoidance test conducted 1h before and after CO exposure. Rats whose carboxyhemoglobin (COHb) in blood was determined after the terminat on of CO exposure were of the same strain and age as those that under went operant behavior test. Exposure of CO 50ppm did not produce any marked change in operant behavior. In male rat groups, response counts in the Sidman avoidance test decreased after exposure to CO 100, 200 and 400ppm when compared to the value before exposure, but increase in shock counts was observed only by exposure to CO 400ppm. In female rat groups, response counts decreased after the exposure to CO 200 and 400ppm, but shock counts did not show any marked change at all the CO exposure concentrations. COHb concentrations in medialety after the exposure to CO 50, 100, 200 and 400ppm for 4h were 9.1±1.2, 13.5±0.5, 24.3±0.7 and 43.6±1.6%, respectively, in males, and 9.2±1.1, 13.7±±0.8, 24.0±1.0 and 42.0±1.4%, respectively, in females. Operant behavioral effect of CO exposure on male rats was more apparent than that on female rats. This finding was related to the difference in COHb decrease rate between male and female rats.
社団法人日本産業衛生学会の論文
1990-01-20

一酸化炭素一回曝露の学習行動影響にみられる性差

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