ラットのレバ-押しによるシドマン回避行動におよぼす鉛の影響

概要

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Effects of asymptomatic lead exposure on Sidman avoidance behavior in rats were studied. The animals were administered asymptomatic doses of lead acetate until 60 days of age through maternal milk while suckling and drinking water after weaning. From 61 days of age, learning patterns for lever pressing and shock avoidance of animals were investigated for one hour every other day for a total of 10 sessions.1) The mean concentration of lead in rats administered 2mg/ml lead was 34.8μg/100g in the blood, and 99.3μg/100g in the brain at 60 days of age, and no significant differences were seen in shock avoidance learning when compared with the control group.2) The mean lead level of lead in rats administered 5mg/ml lead was 73.2μg/100g in the blood, 222.4μg/100g in the brain at 60 days of age, and the acquisition of shock avoidance patterns was significantly delayed in the first five sessions of the learning period when compared with the control group.3) The acquisition of shock avoidance patterens in the 5mg/ml lead group was similar to that of the control group in the second half of the training sessions. These results indicated that reinforcement stimulus by electric shock used on a Sidman avoidance schedule was a very strong reinforcement stimulus of those used in the operant behavior experiments.
日本衛生学会の論文