Morphological study on the initial lesions of experimental primary biliary cirrhosis.

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We extended morphological study on 84 rahbits through the immunization with antigen prepared from fresh bovine gallbladder mucouse membrane in order to clarify the initial lesions and its incidence.<BR>In 47 out of 84 rabbits (56%), preicholangitis with and without granuloma was founded out. In addition, chronic non-suppurative destructive chonlangitis was recognized in six rabbits. This fact indicated that experimental primary biliary cirrhosis model was induced through our experimental methods.<BR>And there's no corellations between the frequency of immunization and the incidence of chronic non-suppurative destructive cholangitis and pericholangitis, therefore it was thought that the individual differential sensitivity existed in the provocation and the development of the disease.
社団法人日本肝臓学会の論文