Saikosaponinの作用機作の解析-2-電子顕微鏡学的所見を中心として

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The action of saikosaponin, which is effective to D-galactosamine induced hepatic injury, to intracellular microorgans of normal rat liver cells was examined quantitatively by electron microscopy.<BR>After 24 hours of injection of saikosaponin 2mg/kg of body weight, the endoplasmic reticulum, especially smooth endoplasmic reticulum, was remarkably increased. The volume density of smooth endoplasmic reticulum to cytoplasm of saikosaponin 2mg/kg treated liver cells was increased to 7.34±1.34% in comparison with 3.77±0.41%.of normal liver cells but the volume density of mitochondria was not changed. In the rat liver treated with saikosaponin 20mg/kg, the volume densities of mitochondria and golgi complex significantly increased although the endoplasmic reticulum was not increased.
社団法人日本肝臓学会の論文