Cytosolic and Membrane-Bound Nitric Oxide Synthase
スポンサーリンク
概要
- 論文の詳細を見る
Cytotoxic activated macrophages were sonicated and centrifuged. The activity of nitric oxide (NO) synthase was present in the supernatant and independent of Ca<SUP>2+</SUP>. The pellets were washed three times and treated with buffer containing 0.1% Triton X-100 or buffer alone, followed by centrifugation. The supernatant containing Triton X-100 showed NO synthase activity that was dependent on Ca<SUP>2+</SUP>, whereas the supernatant without the detergent had little activity. These data suggest that there are two forms of NO synthase: cytosolic and membrane-bound enzymes.
著者
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HATTORI RYUICHI
Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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YUI YOSHIKI
Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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HIKI KAZUAKI
Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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Yui Yoshiki
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Hiki Kazuaki
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kosuga Kunihiko
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Hattori Ryuichi
Third Division Department Of Internal Medicine Faculty Of Medicine
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Kawai Chuichi
Third Department Of Internal Medicine Kyoto University Faculty Of Medicine
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Eizawa Hiroshi
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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