Effect of Ebselen on Bovine and Rat Nitric Oxide Synthase Activity Is Modified by Thiols
スポンサーリンク
概要
- 論文の詳細を見る
The inhibition of nitric oxide synthase (NOS) by ebselen, 2-phenyl-1, 2-benzisoselenazole-3(2<I>H</I>)-one, was reversed by the addition of 10<SUPminus;5</SUP> M dithiothreitol, suggesting that ebselen reacts with a critical thiol group of NOS in the inhibitory mechanism. In the presence of 10<SUP>minus;4</SUP> to 10<SUP>minus;3</SUP> M dithiothreitol, ebselen dose-dependently enhanced NOS activity, implicating another interaction of ebselen with NOS under these conditions. Thus, the effect of ebselen on the NOS activity is modified by thiols.
- 社団法人 日本薬理学会の論文
著者
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Hattori R
Jj-mic(b) : Japan Multicenter Investigation For Cardiovascular Diseases (b) Study Group
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Shinoda Eiji
The Japan Multicenter Investigation For Cardiovascular Diseases-b (jmic-b) Study Group
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Hattori Ryuichi
Third Division Department Of Internal Medicine Faculty Of Medicine
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Yazaki Yoshio
The Third Dept. Of Medicine University Of Tokyo
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Hattori Ryuichi
Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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Yui Yoshiki
Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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Shinoda Eiji
Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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Inoue Reiko
Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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Aoyama Takeshi
Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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Masayasu Hiroyuki
Medical Research & Development Department III, Daiichi Pharmaceutical Co., Ltd.
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Kawai Chuichi
Kyoto University
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Sasayama Shigetake
Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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Yui Yoshiki
<I>Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University</I>
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Sasayama Shigetake
<I>Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University</I>
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Aoyama Takeshi
<I>Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University</I>
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Kawai Chuichi
<I>Kyoto University</I>
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Hattori Ryuichi
<I>Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University</I>
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Inoue Reiko
<I>Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University</I>
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Shinoda Eiji
<I>Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University</I>
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Masayasu Hiroyuki
<I>Medical Research & Development Department III, Daiichi Pharmaceutical Co., Ltd.</I>
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