HEPARIN REQUIREMENT IN TISSUE-TYPE PLASMINOGEN ACTIVATOR-INDUCED EXPERIMENTAL CORONARY THROMBOLYSIS : COMPARISON WITH UROKINASE-INDUCED CORONARY THROMBOLYSIS

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概要

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• The requirement of heparin in experimental coronary thrombolysis induced by tissue-type plasminogen activator (t-PA) was studied in closed-chest dogs with one hour old coronary thrombi and compared with that in urokinase (UK)-induced coronary thrombolysis. Animals were divided into 5 treatment groups as follows: group 1 received intracoronary t-PA along (1,000 IU/kg/min; n=5), and if thrombolysis was not induced within 40 to 50 min, dogs then received an intravenous injection of heparin (300 U/kg) plus intracoronary t-PA; group 2 received intravenous heparin at first, and if thrombolysis was not induced within 10 min, dogs subsequently received intracoronary t-PA (n=5); group 3 also received intravenous heparin at first, and if thrombolysis was not induced within 10 min, dogs subsequently received t-PA but intravenously, as compared with the groups administered by the intracoronary route (n=6); group 4 received intracoronary UK alone (1,000 IU/kg/min; n=6); group 5 received intravenous heparin at first, and if thrombolysis was not induced within 10 min, dogs subsequently received intracoronary UK (n=5). Thrombolysis was confirmed angiographically. In group 1, coronary thrombolysis could not be induced within 444 min by intracoronary t-PA alone, but it occurred in 84 min when administered in combination with heparin in all dogs. Heparin alone failed to elicit reperfusion within 10 min in group 2, 3 and 5. t-PA, however, induced successful reperfusion in 165 min (group 2) and in 236 min (group 3), respectively. Intracoronary urokinase alone elicited thrombolysis in 274 min in group 4, but in group 5, treated in combination with heparin, rapid reperfusion was obtained in 125 min (p<0.001).

• 社団法人日本循環器学会の論文
• 1987-04-20

著者

• Susawa Takashi

  Department Of Cardiology Takeda Hospital

• Aoyama Takeshi

  Third Division Department Of Internal Medicine Kyoto University

• Aoyama Takeshi

  京都大学 医研究 循病態

• Hattori R

  Jj-mic(b) : Japan Multicenter Investigation For Cardiovascular Diseases (b) Study Group

• HATTORI RYUICHI

  Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

• YUI YOSHIKI

  Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

• SAKAGUCHI KEIJI

  Heart Center, Rakuyou Hospital

• TAKAHASHI MAMORU

  Heart Center, Rakuyou Hospital

• Kawai Chuichi

  Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• TAKAHASHI Mamoru

  Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

• SUSAWA TAKASHI

  Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

• TAKATSU YOSHIKI

  Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

• SAKAGUCHI KEIJI

  Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

• YUI NATSUKO

  Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

• Yui Yoshiki

  Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Takatsu Yoshiki

  Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Yui Natsuko

  Third Division Department Oflnternal Medicine Faculty Of Medicine Kyoto University

• Sakaguchi Keiji

  Heart Center Rakuyou Hospital

• Aoyama Takeshi

  Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Sakaguchi Keiji

  The Third Division Department Of Internal Medicine Kyoto University

• Hattori Ryuichi

  Third Division Department Of Internal Medicine Faculty Of Medicine

• Takahashi Mamoru

  Heart Center Rakuyou Hospital

• Yazaki Yoshio

  The Third Dept. Of Medicine University Of Tokyo

• Kawai Chuichi

  Third Department Of Internal Medicine Kyoto University Faculty Of Medicine

• Sase Kazuhiro

  京都大学 第3内科

• Susawa Takashi

  Third Division Internal Medicine Faculty Of Medicine Kyoto University

• Takahashi Mamoru

  Third Department of Internal Medicine, Sapporo Medical University School of Medicine

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