ENHANCEMENT OF CORONARY THROMBOLYSIS WITH PLASMINOGEN PRO-ACTIVATOR BY PRETREATMENT WITH HEPARIN
スポンサーリンク
概要
- 論文の詳細を見る
The effect of pretreatment with heparin on coronary thrombolysis by plasminogen pro-activator was studied in 20 dogs with a 1-h old clot in the left anterior descending coronary artery. The clot was induced by placement of a copper coil and thrombolysis was confirmed angiographically. Intravenous administration of plasminogen pro-activator at a rate of 5 μg/kg/min (group 1; n = 5) and 20 μg/kg/min (group 2; n = 5) after pretreatment with heparin (300 IU/kg) induced thrombolysis in 31 ± 4 min and 14 ± 2 min, respectively. When plasminogen pro-activator was administrated intravenously at a rate of 20 μg/kg/min without heparin pretreatment (group 3; n = 5), the infusion interval for successful thrombolysis was prolonged to 45 ± 6 min, which was significantly longer than that in groups 1 and 2 (p < 0.001). In these three treatment groups, thrombolysis was not associated with severe alteration in plasma hemostatic factors (fibrinogen and alpha_2-antiplasmin). An evaluation of plasma urokinase activities using a chromogenic substrate S-2444 did not showed that heparin increased the plasma urokinase activities. By increasing the dose of plasminogen pro-activities. By increasing the dose of plasminogen pro-activator to 80 g/kg/min, successful reperfusion was rapidly obtained in 25 5 min without heparin pretreatment (group 4; n = 5); this was significantly faster than the results seen in group 3 (p <0.001). An analysis of urokinase activities showed that plasminogen pro-activator was fully converted to urokinase, which induced complete depletion of fibrinogen and alpha_2-antiplasmin. These results suggest that heparin can enhance coronary thrombolysis in dogs and the mechanism of the enhancement is not related to the plasma urokinase activities. In addition, heparin may reduce the risk of the depletion of plasma fibrinogen by lowering the doses of plasminogen pro-activator necessary for reperfusion.
- 社団法人日本循環器学会の論文
- 1988-01-20
著者
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Susawa Takashi
Department Of Cardiology Takeda Hospital
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Aoyama Takeshi
Third Division Department Of Internal Medicine Kyoto University
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Aoyama Takeshi
京都大学 医研究 循病態
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Hattori R
Jj-mic(b) : Japan Multicenter Investigation For Cardiovascular Diseases (b) Study Group
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HATTORI RYUICHI
Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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TAKAHASHI MAMORU
Heart Center, Rakuyou Hospital
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SHIROTANI MANABU
Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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MUROHARA Yoshiharu
Third Division, Department of internal medicine, Kyoto University Hospital
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Kawai Chuichi
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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TAKAHASHI Mamoru
Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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TAKATSU YOSHIKI
Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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SUSAWA TAKASHI.
Third Division, Department oflnternal Medicine, Faculty of Medicine, Kyoto University
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YUl YOSHIKI
Third Division, Department oflnternal Medicine, Faculty of Medicine, Kyoto University
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YUl NATSUKO
Third Division, Department oflnternal Medicine, Faculty of Medicine, Kyoto University
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Takatsu Yoshiki
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Yui Natsuko
Third Division Department Oflnternal Medicine Faculty Of Medicine Kyoto University
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Aoyama Takeshi
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Hattori Ryuichi
Third Division Department Of Internal Medicine Faculty Of Medicine
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Shirotani Mamoru
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Takahashi Mamoru
Heart Center Rakuyou Hospital
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Murohara Yoshiharu
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Shirotani Manabu
Dept. Of Cardiology Kokura Memorial Hosp.
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Yazaki Yoshio
The Third Dept. Of Medicine University Of Tokyo
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Kawai Chuichi
Third Department Of Internal Medicine Kyoto University Faculty Of Medicine
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Takahashi Mamoru
Third Department of Internal Medicine, Sapporo Medical University School of Medicine
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