PLATELET AGGREGATION AND THROMBOXANE B_2 RELEASE IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION : Their Relation to Coronary Patency

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• Platelet function in the aortic blood in 39 patients who underwent intracoronary thrombolysis with urokinase was evaluated in the acute stage of myocardial infarction and after 4 weeks. The patients were classified into 2 groups according to the patency of the infarct vessel shown by coronary arteriography before urokinase administration. In the acute stage, 26 patinets with completely occluded infarct vessel (group 1) showed a decreased level of platelet aggregation induced by adenosine diphosphate or arachidonic acid as compared with 13 patients with patent infarct vessel (group 2). The platelet aggregation in group 1 increased 4 weeks later and both groups showed similarly enhanced platelet aggregation levels as compared with normal controls. Like platelet aggregation, serum thromboxane B_2 production in group 1 was lower than that in group 2 in the acute stage. Plasma thromboxane B_2 levels in the aorta in both groups were significantly elevated in the acute stage, and were normalized after 4 weeks. This elevation of thromboxane B_2 seems to be due to its washout from the infarct vessel, because plasma thromboxane B_2 levels were significantly higher in the great cardiac vein than those in the aorta after successful reperfusion in group 1 or group 2. In conclusion, despite a significant elevation in plasma thromboxane B_2 levels, platelet aggregation and serum thromboxane B_2 production relatively decrease in patients with totally occluded infarct vessel. The patency of the infarct vessels should be taken into account when evaluating platelet function in acute myocardial infarcion.

• 社団法人日本循環器学会の論文
• 1988-04-20

著者

• Susawa Takashi

  Department Of Cardiology Takeda Hospital

• Tamaki Shunichi

  Cardiology Division Takeda Hospital

• Tamaki Shunichi

  Division Of Cardiology Kyoto Takeda Hospital

• Aoyama Takeshi

  Third Division Department Of Internal Medicine Kyoto University

• Aoyama Takeshi

  京都大学 医研究 循病態

• Hattori R

  Jj-mic(b) : Japan Multicenter Investigation For Cardiovascular Diseases (b) Study Group

• HATTORI RYUICHI

  Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

• YUI YOSHIKI

  Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

• SAKAGUCHI KEIJI

  Heart Center, Rakuyou Hospital

• TAKAHASHI MAMORU

  Heart Center, Rakuyou Hospital

• Kawai Chuichi

  Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Tamaki Shunichi

  Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• TAKAHASHI Mamoru

  Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

• SUSAWA TAKASHI

  Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

• TAKATSU YOSHIKI

  Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

• SAKAGUCHI KEIJI

  Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

• YUI NATSUKO

  Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

• Yui Yoshiki

  Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Takatsu Yoshiki

  Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Yui Natsuko

  Third Division Department Oflnternal Medicine Faculty Of Medicine Kyoto University

• Sakaguchi Keiji

  Heart Center Rakuyou Hospital

• Aoyama Takeshi

  Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Sakaguchi Keiji

  The Third Division Department Of Internal Medicine Kyoto University

• Hattori Ryuichi

  Third Division Department Of Internal Medicine Faculty Of Medicine

• Takahashi Mamoru

  Heart Center Rakuyou Hospital

• Yazaki Yoshio

  The Third Dept. Of Medicine University Of Tokyo

• Kawai Chuichi

  Third Department Of Internal Medicine Kyoto University Faculty Of Medicine

• Sase Kazuhiro

  京都大学 第3内科

• Tamaki Shunichi

  Cardiovasc. Div. Shiga Mediecal Center For Adult Dis.

• Susawa Takashi

  Third Division Internal Medicine Faculty Of Medicine Kyoto University

• Takahashi Mamoru

  Third Department of Internal Medicine, Sapporo Medical University School of Medicine

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