Thrombolysis with Intracoronary Administration of YM866, a Novel Modified Tissue-Type Plasminogen Activator, in a Canine Model of Coronary Artery Thrombosis.
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概要
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We compared the thrombolytic activity of YM866, a novel modified tissue-type plasminogen activator, with that of t-PA by intracoronary administration in a canine thrombosis model of copper coil-induced 6-hr-old thrombi. Either drug was administered by a single injection (10 min) or multiple injection (4×10 min) under heparinization (300 IU/kg, i.v.). The reperfusion rate of YM866 was 4 times higher than that of t-PA when administered by single injection. Time to reperfusion of YM866 by single injection was shorter than that of either agent by multiple injection. No group showed any decrease in plasma fibrinogen levels. No acute reocclusion was seen in animals with YM866 by single injection. The improved thrombolytic activity of YM866 by single injection correlated with the relatively higher antigen levels of this agent due to its prolonged biological half-life. These results suggest that single intracoronary administration of YM866 is a safe and effective thrombolytic method for rapid recanalization and lowered acute reocclusion without activation of systemic fibrinolysis.
- 公益社団法人 日本薬理学会の論文
著者
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Yui Yoshiki
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Katoh Masao
Molecular Medicine Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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Kawai Chuichi
Third Department Of Internal Medicine Kyoto University Faculty Of Medicine
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Kaku Seiji
Cardiovascular and Atherosclerosis Research Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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Kawasaki Tomihisa
Cardiovascular and Atherosclerosis Research Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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Gushima Hiroshi
Research Strategy and Evaluation Division, Yamanouchi Pharmaceutical Co., Ltd.
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Takenaka Toichi
Cardiovascular and Atherosclerosis Research Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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GUSHIMA Hiroshi
Research Institute for Food Science, Kyoto University
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Katoh Masao
Molecular Medicine Research, Yamanouchi Pharmaceutical Co., Ltd.
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