飼料給与条件下におけるヒツジの血糖維持に対するグルココルチコイドの効果〔英文〕

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To determine the contribution of glucocorticoids for the maintenance of plasma glucose levels in ruminants, this study used nine adrenalectomized (ADX) sheep under fed conditions. Experiments 1, 2 and 3 were performed to investigate the effects of glucocorticoids on plasma glucose levels. In each experiment plasma glucose levels were evaluated in the same animals during the three periods of intact, adrenalectomy plus glucocorticoid administration and withdrawal of glucocorticoid administration. Further, in experiment 3 plasma cortisol levels were also determined on three successive days in the above mentioned periods. 1) The plasma glucose levels during the glucocorticoid therapy period in experiment 1 (cortisone) and in experiment 2 (cortisol) after adrenalectomy were 10-20% significantly higher than the control values [57.4±1.2 (mean±S. E.) mg/100ml] before adrenalectomy (P<0.05), but in experiment 3 (cortisol) the levels were similar to the control values. The difference in plasma glucose levels between experiments 2 and 3 might be influenced by the different doses of glucocorticoid (experiment 2: 0.42mg/kg body weight, experiment 3: 0.25mg/kg body weight). 2) However, in any experiment the levels of plasma glucose following withdrawal of the hormone declined rapidly to 10-25% lower than the control values and the difference was significant (P<0.05). 3) The plasma cortisol levels during the glucocorticoid therapy period (18-20th days: 9.2±0.4ng/ml) in experiment 3 were significantly higher than the control values (7.0±1.0ng/ml) (P<0.05). The levels following the withdrawal (11-13th days: 2.2±0.4ng/ml, 25-27th days: 0.8±0.1ng/ml) also declined rapidly (P<0.05). It is concluded that glucocorticoids contribute to some extent for the maintenance of plasma glucose levels under fed conditions in ruminants, presumably as a result of stimulating gluconeogenesis in fed sheep.
社団法人日本畜産学会の論文

飼料給与条件下におけるヒツジの血糖維持に対するグルココルチコイドの効果〔英文〕

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