Tonic Block of the Sodium and Calcium Currents by Ketamine in Isolated Guinea Pig Ventricular Myocytes.
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概要
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Effects of ketamine on the sodium (INa) and L-type calcium currents (ICa) were examined by using whole-cell patch clamp techniques in guinea pig single ventricular myocytes. The mode of action of ketamine was compared with those of quinidine, a sodium channel blocker, and verapamil, a calcium channel blocker. Ketamine (30-300 μM) inhibited both INa and ICa in a concentration-dependent manner. Quinidine (30 μM) and verapamil (0.1 μM) produced use-dependent depression of INa and ICa, respectively. The amplitude of INa elicited by the first depolarizing pulse after a long quiescent period was slightly decreased by quinidine. During a train of depolarizing pulse the current amplitude decreased gradually, and reached a steady state level in the quinidine-treated cells (use-dependent block, UDB). Verapamil produced a similar mode of inhibition of ICa, i.e., UDB. In contrast, ketamine produced significant decrease in INa and ICa elicited by the first depolarizing pulses and the decreases of both currents were not augmented during a train of depolarizing pulses. From these results, it can be concluded that ketamine produces tonic block of the cardiac sodium and calcium channels and the mode of inhibition is clearly different from UDB by quinidine and verapamil.
- 公益社団法人 日本獣医学会の論文
著者
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Hara Yukio
Department Of Veterinary Pharmacology School Of Veterinary Medicine And Animal Sciences Kitasato Uni
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Nakaya Haruaki
Department Of Orthopaedic Surgery And Pharmacology School Of Medicine Chiba University
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CHUGUN Akihito
Department of Veterinary Pharmacology. School of Veterinary Medicine and Animal Sciences, Kitasato U
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Kondo Hiroshi
Department Of Agricultural Chemistry College Of Agriculture And Veterinary Medicine Nihon University
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KONDO Hiroshi
Department of Veterinary Pharmacology, School of Veterinary Medicine and Animal Sciences, Kitasato University
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CHUGUN Akihito
Department of Veterinary Pharmacology, School of Veterinary Medicine and Animal Sciences, Kitasato University
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