Diazepam Increases Calcium Sensitivity of the Skinned Cardiac Muscle Fiber in Guinea Pig
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概要
- 論文の詳細を見る
Influences of diazepam, a benzodiazepine derivative, on the contractile response to calcium in skinned trabecular fibers of guinea pig heart were examined. Diazepam (100 μM) enhanced the contractile response of the skinned fiber to calcium and shifted the concentration-response curve to the left. The pCa50 values were 6.07±0.03 and 6.28±0.03 (P<0.05) in the absence and presence of diazepam, respectively. This result suggests that diazepam increases calcium sensitivity of contractile proteins in heart muscles.
- 社団法人 日本薬理学会の論文
著者
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NISHINO Takeshi
Department of Microbiology, Kyoto Pharmaceutical University
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Nishino Takeshi
Department Of Biochemistry And Molecular Biology Nippon Medical School
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Hara Yukio
Department Of Veterinary Pharmacology School Of Veterinary Medicine And Animal Sciences Kitasato Uni
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Hara Yukio
Department Of Veterinary Pharmacology. School Of Veterinary Medicine And Animal Sciences Kitasato Un
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KONDO Hiroshi
Department of Civil Engineering, School of Engineering
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CHUGUN Akihito
Department of Veterinary Pharmacology. School of Veterinary Medicine and Animal Sciences, Kitasato U
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FUTAMURA Keisuke
Department of Veterinary Pharmacology. School of Veterinary Medicine and Animal Sciences, Kitasato U
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Futamura Keisuke
Department Of Veterinary Pharmacology. School Of Veterinary Medicine And Animal Sciences Kitasato Un
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Nishino Takeshi
Department Of Veterinary Pharmacology. School Of Veterinary Medicine And Animal Sciences Kitasato Un
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Kondo Hiroshi
Department Of Agricultural Chemistry College Of Agriculture And Veterinary Medicine Nihon University
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Kondo Hiroshi
Department Of Veterinary Pharmacology. School Of Veterinary Medicine And Animal Sciences Kitasato Un
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CHUGUN Akihito
Department of Veterinary Pharmacology, School of Veterinary Medicine and Animal Sciences, Kitasato University
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