Difference in migratory ability between human lung and skin fibroblasts : Cell Biology and Morphology
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概要
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TIG-3 human lung fibroblasts were found to differ in their migratory ability from TIG-3S human skin fibroblasts derived from the same fetus: (1) TIG-3 cells migrated in medium supplemented with 10% fetal bovine serum (FBS) more slowly than TIG-3S cells. (2) TIG-3 cells migrated in serum-free medium as effectively as in medium supplemented with 10% FBS, whereas TIG-3S cells migrated in serum-free medium much more slowly than in medium supplemented with 10% FBS. (3) The migration of TIG-3S cells was changed more markedly by the pH of the culture medium than that of TIG-3 cells. The second was the most striking difference in migratory ability between the TIG-3 and TIG-3S cells, and was also the case when several human fetal lung fibroblasts (TIG-1, TIG-7, WI-38, IMR-90, MRC-5), and skin fibroblasts from adult and elderly donors were tested. The monovalent ionophore, monensin, inhibited the migration of TIG-3 and TIG-3S cells in our experimental system according to monensin concentration, and immunofluorescence staining for fibronectin demonstrated that monensin inhibited the secretion of fibronectin. This implies that secreted substances including fibronectin regulate cell migration. However, the migration of TIG-3S cells was not decreased to the same degree as that of TIG-3 cells after monensin treatment. The role of the extracellular matrix in this difference of migratory ability between human lung and skin fibroblasts is discussed
- 社団法人日本動物学会の論文
- 1990-02-15
著者
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KONDO Hiroshi
Department of Civil Engineering, School of Engineering
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Yonezawa Y
Tokyo Metropolitan Inst. Gerontology Tokyo Jpn
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Yonezawa Yumiko
Department Of Experimental Biology Tokyo Metropolitan Institute Of Gerontology
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Nomaguchi Takashi
Department of Cell Biology, Tokyo Metropolitan Institute of Gerontology
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Nomaguchi Takashi
Department Of Biology Tokyo Metropolitan Institute Of Gerontology
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Kondo Hiroshi
Department Of Agricultural Chemistry College Of Agriculture And Veterinary Medicine Nihon University
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Kondo Hiroshi
Department Of Biology Tokyo Metropolitan Institute Of Gerontology
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