Effects of Nicorandil on the cAMP-Dependent Cl^- Current in Guinea-Pig Ventricular Cells
スポンサーリンク
概要
- 論文の詳細を見る
In guinea-pig cardiomyocytes, a cAMP-dependent Cl− current (ICl,cAMP) flows through a cardiac isoform of the cystic fibrosis transmembrane conductance regulator (CFTR), which belongs to a family of the ATP-binding cassette (ABC) proteins. Although several K+-channel openers and sulfonylurea ATP-sensitive K+ (KATP)–channel blockers reportedly inhibit ICl,cAMP, effects of nicorandil on the Cl− current have not been evaluated. This study was conducted to examine the effects of nicorandil on ICl,cAMP in isolated guinea-pig ventricular cells using patch clamp techniques. Nicorandil in concentrations higher than 300 μM enhanced the ICl,cAMP preactivated by 0.1 μM isoproterenol. The isoproterenol-induced ICl,cAMP was inhibited by 100 μM glibenclamide, but not by 100 μM pinacidil. SNAP (S-nitroso-N-acetyl-D,L-penicillamine, 10 μM), a nitric oxide (NO) donor, similarly enhanced the isoproterenol-induced ICl,cAMP. However, SG-86, a denitrated metabolite possessing K+ channel–opening action, failed to enhance the Cl− current. When the ICl,cAMP was activated by 3-isobutyl-1-methylxanthine (IBMX, 30 μM), either nicorandil or SNAP failed to enhance the isoproterenol-induced ICl,cAMP. Thus, nicorandil enhances ICl,cAMP in guinea-pig cardiomyocytes through an increase in intracellular cGMP, although direct modulation of ICl,cAMP by NO cannot be completely excluded.
- 2010-04-20
著者
-
Nakaya Haruaki
神戸大学 医学部
-
Doi Hiroshi
群馬大学 医学系研究科臓器病態内科学
-
Daida Hiroyuki
順天堂大学 医学部循環器内科学
-
Daida Hiroyuki
順天堂大学 循環器内科
-
OGURA Takehiko
Department of Pharmacology, Chiba University Graduate School of Medicine
-
Nakazato Yuji
順天堂大学 医学部循環器内科学
-
Nakazato Yuji
国際親善総合病院 循環器内科
-
Ogura Takehiko
Dep. Of Pharmacology Chiba Univ. Graduate School Of Medicine Jpn
-
Ogura Takehiko
Department Of Pharmacology Chiba University Graduate School Of Medicine
-
Nakaya Haruaki
慶応義塾大学 医学部
-
Nakata Yasurou
順天堂大学医学部附属伊豆長岡病院 循環器内科
-
REIEN Yoshie
Department of Pharmacology, Chiba University Graduate School of Medicine
-
Nakaya Haruaki
Department Of Orthopaedic Surgery And Pharmacology School Of Medicine Chiba University
-
Daida Hiroyuki
Department Of Cardiology
-
Nakaya Haruaki
Department Of Pharmacology Chiba University School Of Medicine
-
Nakazato Yuji
Department Of Cardiology Heart Center Juntendo University Urayasu Hospital
-
Nishimura Nami
Department Of Cardiology Ageo Central General Hospital
-
Matsumoto Akio
Department Of Biochemistry Osaka University Medical School
-
Suzuki Kazumasa
Department Of Psychiatry Tohoku University Hospital
-
Reien Yoshie
Department Of Pharmacology Chiba University Graduate School Of Medicine
-
Miyata Yuuichi
Department Of Pharmacology Chiba University Graduate School Of Medicine
-
Suzuki Kazumasa
Department Of Pharmacology Chiba University Graduate School Of Medicine
-
Suzuki Kazumasa
Department Of Otorhinolaryngology Chiba University School Of Medicine
-
Matsumoto Akio
Department Of Pharmacology Chiba University Graduate School Of Medicine
-
Nishimura Nami
Department Of Pharmacology Chiba University Graduate School Of Medicine
-
Matsumoto Akio
Dep. Of Pharmacology Chiba Univ. Graduate School Of Medicine Jpn
-
NAKAZATO Yuji
Department of Cardiology, Juntendo University School of Medicine
関連論文
- Clinical Characteristics of Defecation Syncope Compared With Micturition Syncope
- Prevalence of the Brugada-Type Electrocardiogram and Incidence of Brugada Syndrome in Patients With Sick Sinus Syndrome
- Glimepiride Treatment Upon Reperfusion Limits Infarct Size via the Phosphatidylinositol 3-Kinase/Akt Pathway in Rabbit Hearts
- Age-Dependent Clinical Characteristics of Micturition Syncope
- PJ-675 Deletion of Fc Receptor Reduces Atherosclerotic Lesions in LDL Receptor Knockout Mice : Role of Protection against Inflammation and Oxidative Stress(PJ113,Atherosclerosis, Basic 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting o
- 2 GATA3 is Essential for Tie2 Expression and its signaling in Endothelium(Young Investigator's Award for International Students Finalists Lecture (YIA International),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- DPE-063 Prognostic Value of Urinary Liver-type Fatty Acid-Binding Protein (L-FABP) in Patients with Acute Coronary Syndrome(DPE11,Kidney/Renal Circulation/CKD (H),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulat
- PJ-754 Intravascular Ultrasound Analysis of Coronary Atheroma in Patients with and without Chronic Kidney Disease following Statin Therapy from JAPAN-ACS Study(PJ127,Intravascular Imagings 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting
- Diabetes Mellitus Is a Major Negative Determinant of Coronary Plaque Regression During Statin Therapy in Patients With Acute Coronary Syndrome : Serial Intravascular Ultrasound Observations From the Japan Assessment of Pitavastatin and Atorvastatin in Acu
- Changes of Matrix Metalloproteinase-9 Level Is Associated With Left Ventricular Remodeling Following Acute Myocardial Infarction Among Patients Treated With Trandolapril, Valsartan or Both
- FRS-009 Crucial roles of PDK1 in the regulation of β-adrenergic response and cell survival in the hearts(Novel Pathophysiological Mechanisms of Heart Failure(M),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Socie
- OE-056 Erythropoietin Prevents LV Remodeling after Myocardial Infarction through Erythropoietin Receptor-Induced Signaling Pathways in the Heart(Acute myocardial infarction, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-242 Erythropoietin Has an Ischemic Postconditioning-like Effect on Myocardium through a Direct Action on Cardiomyocytes(Myocardial ischemia-reperfusion, basic/clinical-2 (M) OJ41,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeti
- The Direct Effects of G-CSF on Cardioprotection against Ischemia/Reperfusion Injury(Myocardial Ischemia-reperfusion, Basic 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Optimal Treatment Strategy for Patients With Paroxysmal Atrial Fibrillation : J-RHYTHM Study(Arrhythmia/Electrophysiology)
- Diabetes Mellitus Is a Major Negative Determinant of Coronary Plaque Regression During Statin Therapy in Patients With Acute Coronary Syndrome : Serial Intravascular Ultrasound Observations From the Japan Assessment of Pitavastatin and Atorvastatin in Acu
- Rationale and Design of a Study to Examine Lower Targets for Low-Density Lipoprotein-Cholesterol and Blood Pressure in Coronary Artery Disease Patients : The Japanese Coronary Artery Disease Study II (JCADII)
- Clinical Significance of Intensive Lipid-Lowering Therapy Using Statins in Patients With Coronary Artery Disease : LDL-Cholesterol : The Lower, the Better ; Is It True for Asians? (Pro)
- OE-056 Non-HDL Cholesterol is Strong Predictor in Metabolic Syndrome for Long-Term Ten-Year Outcomes in Japanese Patients Undergoing CABG Surgery(Lipid disorders-1 (H) OE10,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the
- FRS-107 Early Pharmacological Intervention with Atorvastatin Regulates Th1/Th2 Imbalance in Patients with Acute Coronary Syndrome(Acute Coronary Syndrome (IHD) : FRS13)(Featured Research Session (English))
- Concentrations of Th1/Th2 Cytokines and C-Reactive Protein in Patients with Coronary Atherosclerosis and Acute Coronary Syndrome
- Circulating Oxidized Low-Density Lipoprotein Is an Independent Predictor for Cardiac Events in Patients with Coronary Artery Disease
- Ten-Year Follow-Up of Mortality in Patients Undergoing PCI and CABG
- Common polymorphism of CD14 monocyte receptor gene and concentrations of soluble CD14 in patients with restenosis after elective coronary stenting
- Randomized Trial of the Long-term Effects of Pravastatin on Coronary Artery Bypass Grafts : PCAB Study(Enrollment number : 60013)
- Potentially Protective Effects of the Ser447-Ter Mutation of the Lipoprotein Lipase Gene Against the Development of Coronary Artery Disease in Japanese Subjects Via a Beneficial Lipid Profile
- Association of Seropositivity for Antibody to Chlamydia-Specific Lipopolysaccharide and Coronary Artery Disease in Japanese Men
- Arrhythmogenic Right Ventricular Cardiomyopathy With an Initial Manifestation of Severe Left Ventricular Impairment and Normal Contraction of the Right Ventricle
- Local Delivery Infusion Pressure is a Key Determinant of Vascular Damage and Intimal Thickening
- 0815 Percutaneous Transluminal Coronary Angioplasty in Patients with Multivessel Coronary Disease : Dose Complete Revascularization Improve the Long Term Survival?
- 0331 The relation between HDL subclasses and coronary artery disease in individuals with a predominance of small LDL and low HDL cholesterolemia
- PJ-734 Impact of Chronic Kidney Disease on Severity of Coronary Artery Disease(PJ123,Kidney/Renal Circulation/CKD 6 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-040 The Impact of Chronic Kidney Disease on Long-term Outcome after Acute Coronary Syndrome, over a 10-Year Follow Up Period(PJ007,Kidney/Renal Circulation/CKD 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulati
- PE-374 Propensity Analysis of Long-term Outcome (Total-mortality and Acute Coronary Syndrome) of Drug-Eluting Stents versus Bare-Metal Stents(PE063,Coronary Revascularization, PCI (DES) 5 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting o
- PE-136 Effects of Calcium-channel Blocker and Angiotensin-Receptor Blocker on Endothelial Dysfunction and Inflammation Induced by Drug-Eluting Stent(PE023,Coronary Revascularization, PCI (DES) 3 (IHD),Poster Session (English),The 73rd Annual Scientific Me
- DPJ-011 Chronic Kidney Disease Predicts Long-term Mortality after Coronary Artery Bypass Surgery in Patients with and without Metabolic Syndrome(DPJ02,Cardiovascular Surgery/CABG (IHD),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting o
- OJ-223 Propensity Analysis of Long-term Outcome of Coronary Artery Bypass Graft versus Balloon Angioplasty in Patients with Chronic Kidney Disease(OJ38,Atherosclerosis (Clinical/Treatment) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meet
- OJ-182 Long-term Outcome after an Early Statin Treatment in Patients with Acute Coronary Syndrome (Extended-ESTABLISH trial) : A Long-Term Follow up Results(OJ31,ACS/AMI (Clinical/Treatment) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Me
- OJ-162 Clinical Implication of Measurement of Serum NT-ProBNP Level in Patients with Coronary Artery Disease(OJ27,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The J
- OJ-026 Differences in Vascular Response and Renal Function following Moderate or Aggressive Lipid Lowering Therapy in Hypercholesterolemic Patients with Cardiovascular Diseases(OJ05,Peripheral Circulation/Vascular Disease (Therapy) 1 (H),Oral Presentation
- OE-361 Fasting Triglyceride Level is a Risk Factor for 10-years Long-Term Cardiac Death among Patients who Underwent Complete Coronary Revascularization(OE61,Lipid Disorders (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanes
- OE-349 Beneficial Effect of Sirolimus-Eluting Stents versus Bare Metal Stents following Rotational Atherectomy on Long-term Cardiovascular Events(OE59,Coronary Revascularization, PCI (Complex Lesions) (IHD),Oral Presentation (English),The 73rd Annual Scie
- OE-166 Long-Term Outcomes of Sirolimus-Eluting Stent versus Off-pump Coronary Artery Bypass Grafting in Diabetics with Multivessel Coronary Disease Involving Proximal LAD(OE28,Coronary Revascularization, PCI (Restenosis/Others) 1 (IHD),Oral Presentation (
- FRS-088 Trends in Long-Term Outcomes in Diabetes after Percutaneous Coronary Intervention : A 22-Year Long-term Follow-up in Single Center Registry(FRS18,New Insights into Metabolic Syndrome (H),Featured Research Session (English),The 73rd Annual Scientif
- FRS-057 Short-term Plaque Regression with Intravascular Ultrasound Predicts Long-term Outcomes in Patients with Acute Coronary Syndrome(FRS12,New Approaches to Atherosclerosis Research (IHD),Featured Research Session (English),The 73rd Annual Scientific M
- Dipyridamole Therapy Improves Long-Term Survival After Complete Revascularization in Patients With Impaired Cardiac Function : A Propensity Analysis
- Metabolic Syndrome Predicts 10-Year Mortality in Non-Diabetic Patients Following Coronary Artery Bypass Surgery
- Effectiveness of Statin-Eluting Stent on Early Inflammatory Response and Neointimal Thickness in a Porcine Coronary Model
- PJ-752 Joint Impact of Metabolic Syndrome and Acute Coronary Syndrome on Ten-year Clinical Outcomes(Acute coronary syndrome, basic/ clinical(06)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-097 Combination Therapy of Calcium Channel Blocker and Angiotensin2 Receptor Blocker Improved Endothelial Damage and Inflammation by Drug-Eluting Stent(Endothelium(03)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Cir
- Effect of Rosuvastatin on Coronary Atheroma in Stable Coronary Artery Disease : Multicenter Coronary Atherosclerosis Study Measuring Effects of Rosuvastatin Using Intravascular Ultrasound in Japanese Subjects (COSMOS)
- PJ-754 Intravascular Ultrasound Analysis of Coronary Atheroma in Patients with and without Chronic Kidney Disease following Statin Therapy from JAPAN-ACS Study(PJ127,Intravascular Imagings 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting
- PE-367 Localized Effects of Lipid-lowering Therapy on the Coronary Artery Plaques : Subanalysis of JAPAN-ACS Study(PE062,Atherosclerosis (Clinical/Treatment) (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Soc
- Efficacy and Safety of Controlled-Release Isosorbide-5-Mononitrate in Japanese Patients With Stable Effort Angina Pectoris : A Randomized, Double-Blind, Placebo-Controlled Study
- New Aspects for the Treatment of Cardiac Diseases Based on the Diversity of Functional Controls on Cardiac Muscles : Mitochondrial Ion Channels and Cardioprotection
- OJ-241 Adrenomedullin Potentiates the Opening of Mitochondrial Ca^-Activated K^+ Channels and Reduces Infarct Size in Rabbit Hearts(Myocardial ischemia-reperfusion, basic/clinical-2 (M) OJ41,Oral Presentation (Japanese),The 70th Anniversary Annual Sci
- Effects of Phase III Cardiac Rehabilitation on Mortality and Cardiovascular Events in Elderly Patients With Stable Coronary Artery Disease
- Preventing Angiographic Progression of Coronary Atherosclerosis with Pravastatin
- Sinus Node Dysfunction Concomitant with Brugada Syndrome(Arrhythmia, Diagnosis/Pathophysiology/EPS 6 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-267 Impact of Smoking and HDL-C on Coronary Plaque Regression during Statin Therapy in Acute Coronary Syndrome (ACS) : Sub-analysis of JAPAN-ACS(PE045,ACS/AMI (Clinical/Treatment) 2 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of T
- OE-411 Effect of Statin on Regression of Coronary Artery Disease Assessed by QCA in Patients with ACS Subanalysis of JAPAN-ACS Study(OE69,ACS/AMI (Clinical/Treatment) 2 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese C
- 6 Results of Coronary Atherosclerosis Study Measuring Effects of Rosuvastatin Using Intravascular Ultrasound in Japanese Subjects (COSMOS)(Late Breaking Clinical Trials II,The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Beneficial effects of Waon therapy on patients with chronic heart failure : Results of a prospective multicenter study
- OE-143 Clinical Characteristics of Defecation Syncope : Comparison with Micturition Syncope(OE24,Autonomic Nervous System (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-034 Clinical Characteristics of Micturition Syncope Depending on Age(Autonomic nervous system(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-291 Clinical Efficacy of Bepridil for Class I Antiarrhythmic Drug-Induced Atrial Flutter(Arrhythmia, therapy-19, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-021 Incidence of Spontaneous Ventricular Fibrillation in Patients with Sick Sinus Syndrome and the Brugada-type ECG(Arrhythmia, diagnosis/pathophysiology/EPS-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-316 Clinical Usefullness of Bepridil in the Treatment of Atrial Flutter(Arrhythmia, therapy-14 (A) PJ53,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Effects of Antiarrhythmic Drugs on the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Current
- FRS-069 PDK-1 Plays Essential Roles in Cell Size Regulation, Beta-adrenergic Response and Cell Survival in the Heart(Heart Failure, Cardiac Remodeling and Cardiomyopathy 1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-569 Brown Adipose Tissue Derived-cells Differentiate into Spontaneous Beating Cells with both Cardiac Conduction and Pace-maker Characters(Regeneration (angiogenesis/myocardial regeneration)-4, The 71st Annual Scientific Meeting of the Japanese Circula
- Altered deactivation kinetics modify the inhibitory effects of class III antiarrhythmic drugs on HERG channel
- Vasopressin V_1 - Receptor Stimulation Produces a Positive Inotropic Response without Affecting pH_i in Guinea Pig Papillary Muscles
- Evaluation of the Risk of Drug-Induced Long QT Syndrome : Electrophysiological Analysis Using Native Cardiac Cells and Cultured Cells Expressing HERG Channels(SEMINAR 1 : MODELS FOR PROFILING THE POTENTIAL QTc PROLONGATION RISK OF A DRUG (ICH-57B)ICH SAFE
- Effects of Azimilide on the Muscarinic Acetylcholine Receptor-Operated K^+ Current and Experimental Atrial Fibrillation in Guinea-Pig Hearts
- Sarcolemmal ATP-sensitive K^+ channels and cardiovascular function
- Effects of Nicorandil on the cAMP-Dependent Cl− Current in Guinea-Pig Ventricular Cells
- FRS-171 Role of Na+-Ca2+ Exchanger in Myocardial Ischemia/Reperfusion Injury : Evaluation Using a Heterozygous Na+-Ca2+ Exchanger Knockout Mouse Model(Coronary Heart Disease : Basic Science (IHD) : FRS20)(Featured Research Session (English))
- Characterization of Juvenile Hormone Epoxide Hydrolase and Related Genes in the Larval Development of the Silkworm Bombyx mori
- Effects of lipo-prostaglandin E_1 on blood flow and oxygen pressure in lumbo-sacral nerve roots
- Effects of Bepridil and Amiodarone on Ouabain-Induced Mitochondrial Ca^ Overload in Guinea-Pig Ventricular Cells
- Ischemia-induced electrophysiological alterations in the heart of Kir6.2-deficient mice
- Minoxidil sulfate confers cardioprotection via activation of mitochondrial K_ channels in guinea-pig ventricular myocytes
- ATP-Sensitive K^+ Channel Modulates the Secretion of Atrial Natriuretic Peptide : A Study Using Kir6.2-Deficient Mice (Excitation-contraction Coupling/Ion Channel 2 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Inhibition of ATP-Sensitive K+ Channels and L-Type Ca2+ Channels by Amiodarone Elicits Contradictory Effect on Insulin Secretion in MIN6 Cells
- Effects of Nicorandil on the cAMP-Dependent Cl^- Current in Guinea-Pig Ventricular Cells
- Effects of GABAergic Drugs on the Recovery of Reflex Potentials after Spinal Cord Ischemia in Cats
- EFFECTS OF VARIOUS DRUGS ON CONDUCTION DELAY INDUCED BY ACUTE MYOCARDIAL ISCHEMIA IN DOGS : Arrhythmia II : IInd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- QT PRODACT : Database Construction for the Evaluation of the Risk of QT Interval Prolongation by Drugs in Japan
- PE-357 NS1619 Opens the Mitochondrial Calcium-Activated K^+ Channels and Attenuates the Mitochondrial Ca^ Overload in Guinea-Pig Ventricular Cells(Cardiovascular Pharmacology, Basic/Clinical 4 (H) : PE61)(Poster Session (English))
- Cardioprotective effect of diazoxide is mediated by activation of sarcolemmal ATP-sensitive potassium channels in mouse model
- Inhibition of ATP-Sensitive K^+ Channels and L-Type Ca^ Channels by Amiodarone Elicits Contradictory Effect on Insulin Secretion in MIN6 Cells
- Novel Antiarrhythmic Drugs for the Treatment of Atrial Fibrillation : Current Perspective
- Electropharmacological Profiles of NTC-801, a Novel Selective Acetylcholine-Activated K+ Channel Blocker
- Antiarrhythmic Effects of NTC-801, a Selective Acetylcholine-Activated K+ Channel Blocker, on Experimental Atrial Fibrillation
- Pharmacological Treatment of Atrial Fibrillation: An Overview
- Frequency- and voltage-dependent depression of maximum upstroke velocity of action potentials by primenol in guinea pig ventricular muscles.
- Suppression of lysophosphatidylcholine-induced abnormal automaticity by verapamil in canine Purkinje fibers.
- Does Anti-Inflammatory Action of Amiodarone Explain the High Efficacy in Patients With Heart Failure?
- Tonic Block of the Sodium and Calcium Currents by Ketamine in Isolated Guinea Pig Ventricular Myocytes.