Sequence Analysis and Expression of a Blue-Light Photoreceptor Gene, Le.phrA from the Basidiomycetous Mushroom Lentinula edodes
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概要
- 論文の詳細を見る
The activities of β-carotene on redox status and the immune functions of RAW264 cells, a murine macrophage cell line, were investigated. Supplementation with β-carotene for RAW264 cells resulted in apparently inconsistent redox indices: lipid peroxidation was enhanced but intracellular oxidation was moderately attenuated. Attenuated intracellular oxidation was endorsed by an increase in glutathione accompanied by up-regulated transcription of a subunit of γ-glutamylcysteine synthetase, the rate-limiting enzyme for glutathione synthesis. α-Tocopherol, which can quench lipid peroxidation by free radical, neither inhibited that by β-carotene nor influenced the intracellular redox status. Lipopolysaccharide-stimulated transcriptions of IL-1β and IL-12 p40 in RAW264 were inhibited by β-carotene but not by α-tocopherol. These results indicate that β-carotene, which can modulate the intracellular redox status of macrophages by enhancing the level of intracellular glutathione, is related to the immune functions of macrophages.
- 社団法人 日本農芸化学会の論文
- 2007-09-23
著者
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YAMAZAKI Takashi
Department of Astrophysics, School of Science, Nagoya University
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Sano Hiroaki
Department Of Animal Science Faculty Of Agriculture Tohoku University
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Shishido Kazuo
Department Of Life Science Faculty Of Bioscience And Biotechnology Tokyo Institute Of Technology
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Yamanishi Rintaro
Department Of Food Science Graduate School Of Nutrition And Biosciences The University Of Tokushima
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Sano Hiroaki
Department Of Life Science Graduate School Of Bioscience And Biotechnology Tokyo Institute Of Techno
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Bando Noriko
Department Of Food Science Graduate School Of Nutrition And Bioscience The University Of Tokushima
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Narikiyo Takatsugu
Department Of Life Science Graduate School Of Bioscience And Biotechnology Tokyo Institute Of Techno
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Kaneko Shinya
Department Of Life Science Graduate School Of Bioscience And Biotechnology Tokyo Institute Of Techno
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Kaneko Shinya
Department Of Life Science Graduate School Of Bioscience And Biotechnology Tokyo Institute Of Techno
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Shishido Kazuo
Department Of Life Science Graduate School Of Bioscience And Biotechnology Tokyo Institute Of Techno
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Yamazaki Takashi
Department Of Applied Chemistry Graduate School Of Engineering Tokyo University Of Agriculture And T
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Yamazaki Takashi
Department Of Life Science Graduate School Of Bioscience And Biotechnology Tokyo Institute Of Techno
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Kaneko Shinya
Department Of Anesthesiology Kurume University School Of Medicine
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Imamura Tomomi
Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
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