Ingested β-Carotene Enhances Glutathione Level and up-Regulates the Activity of Cysteine Cathepsin in Murine Splenocytes
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概要
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To elucidate health benefits of β-carotene, especially on immunity, we measured redox-related indices in spleen cells from BALB/c mice supplemented with various amounts of β-carotene. In mice supplemented with β-carotene in their diet, glutathione, an intracellular anti-oxidation agent, increased in their splenocytes. This change was highly correlated with the accumulation of β-carotene, but not with that of retinol. The increase in glutathione was accompanied by an increase in mRNA for γ-glutamylcysteine synthetase, a rate-limiting enzyme for glutathione synthesis. The higher the glutathione content was in the spleen cells, the higher the activity of cysteine cathepsin became in crude antigen-presenting cells contained in the spleen. These data suggest that accumulated β-carotene in splenocytes, without being metabolized, caused an increase in the intracellular glutathione level, thereby anti-oxidatively supporting the activity of redox-sensitive lysosomal protease, which is involved in antigen-presentation.
- 社団法人 日本農芸化学会の論文
- 2008-06-23
著者
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Bando Noriko
Department Of Food Science Graduate School Of Nutrition And Biosciences The University Of Tokushima
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Yamanishi Rintaro
Department Of Food Science Graduate School Of Nutrition And Biosciences The University Of Tokushima
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Bando Noriko
Department Of Food Science Graduate School Of Nutrition And Bioscience The University Of Tokushima
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TAKEDA Saki
Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushim
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Takeda Saki
Department Of Food Science Graduate School Of Nutrition And Biosciences The University Of Tokushima
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Yamanishi Rintaro
Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima
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