Dietary α-Linked Galacto-Oligosaccharide Suppresses Ovalbumin-Induced Allergic Peritonitis in BALB/c Mice

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概要

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• To determine whether α-linked galacto-oligosaccharide (α-GOS) prevents allergic peritonitis, BALB/c mice were fed a synthetic diet with and without α-GOS supplementation for 7 d, and were then subcutaneously immunized with ovalbumin on days 0 and 7. The mice were challenged by intraperitoneal injection with ovalbumin on day 14, followed by peritoneal lavage on day 15. The total number of peritoneal exudate cells was significantly lower in the mice fed the α-GOS diet than in those fed the control diet. Peritoneal lavage fluid from mice fed the α-GOS diet not only had less potency to attract peripheral blood leukocytes and peritoneal exudate cells ex vivo, but also had lower concentrations of monocyte chemoattractant protein-1 (MCP-1) and eotaxin. Preincubation of the cells with α-GOS failed to affect the migration to peritoneal lavage fluid. We propose that dietary α-GOS reduces cell infiltration in allergic peritonitis by reducing antigen-induced elicitation of MCP-1 and eotaxin in mice.

• 社団法人 日本農芸化学会の論文

著者

• WATANABE Jun

  Creative Research Initiative Sousei, Hokkaido University

• Sonoyama Kei

  Laboratory Of Food Biochemistry Division Of Applied Bioscience Graduate School Of Agriculture Hokkai

• HASHIMOTO Hiroyuki

  Department of Applied Biology, Kyoto Institute of Technology

• FUJITA Koki

  Carbohydrate Research Laboratory, Ensuiko Sugar Refining Co., Ltd.

• Mori Shigeharu

  Amano Pharmaceutical Co., Ltd.

• Fujita Koki

  Carbohydrate Research Laboratory Ensuiko Sugar Refining Co. Ltd.

• Kishino Eriko

  Carbohydrate Research Laboratory Ensuiko Sugar Refining Co. Ltd.

• PIRAPATDIT Sooksan

  Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hok

• SAITO Sanshiro

  Fine Chemical Laboratory, J-Oil Mills, Inc.

• SATO Toshiro

  Fine Chemical Laboratory, J-Oil Mills, Inc.

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