Administration of Antibiotics during Infancy Promoted the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

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概要

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• This study aimed to determine whether oral antibiotic administration during infancy is associated with the spontaneous development of atopic dermatitis-like skin lesions by modulating intestinal microbiota. Female NC/Nga mice at 3 weeks of age were orally administered kanamycin or polymyxin B. Clinical symptoms, scratching behavior, and serum antibody levels were evaluated. Changes in intestinal microbiota were determined by culture-independent analysis and cultural analysis. The kanamycin-treated mice showed higher clinical scores and scratching frequency than the control mice. IgE levels were significantly higher in the kanamycin-treated mice than in the control mice. Transient changes in intestinal microbiota were observed under kanamycin treatment. Polymyxin B treatment failed to affect scratching behavior. These results suggest that oral administration of kanamycin during infancy promoted the development of atopic dermatitis-like skin lesions in NC/Nga mice and was associated with a transient change in intestinal microbiota.

• 社団法人 日本農芸化学会の論文

著者

• WATANABE Jun

  Creative Research Initiative Sousei, Hokkaido University

• ITO Susumu

  Creative Research Initiative "Sousei" (CRIS), Hokkaido University

• Watanabe Jun

  Creative Research Initiative Sousei Hokkaido University

• FUJIWARA Reiko

  Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University

• SASAJIMA Naho

  Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University

• SONOYAMA Kei

  Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University

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