Impact of oral administration of compost extract on gene expression in the rat gastrointestinal tract(BREWING AND FOOD TECHNOLOGY)
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概要
- 論文の詳細を見る
Oral administration of an extract consisting of compost fermented with thermophiles to pigs reduces the incidence of stillbirth and promotes piglet growth. However, the mechanism by which the compost extract modulates the physiological conditions of the animals remains largely unknown. Here, we investigate the effects of compost extract on the physiological responses in the intestine of a mammalian rat model. The level of fecal immunoglobulin A (IgA), which provides protection against pathogens and is secreted from the small intestine, was significantly higher in rats treated with continuous administration of the compost extract than in untreated rats after 2 months, but not after 1 month. However, the fecal IgA level was not significantly different in rats that received the filtered compost extract compared with the untreated rats or the rats that received the compost extract. Gene expression analyses of the small intestine indicated that several immune-related genes were upregulated following compost exposure. Specifically, the expression levels of lymphocyte chemoattractant chemokine CXCL13 and Granzyme B, which is released within cytotoxic T lymphocytes and natural killer cells, increased in the small intestinal tract following compost exposure. Based on these observations, it was postulated that the increased level of fecal IgA following compost exposure was associated with the expression of CXCL13 and Granzyme B in the intestinal tract. Thus, thermophile-fermented compost could contain microbes or substances that activate the rat's gut mucosal immune response.
著者
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Nishiuchi Takumi
Division Of Functional Genomics Advanced Science Research Center Kanazawa University
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Matsushita Teruo
Department Of Computer Science And Electronics Kyushu Institute Of Technology
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Satoh Takashi
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Miyamoto Hirokuni
Department of Biochemistry and Integrative Medical Biology, Keio School of Medicine:Miroku Co. Ltd.:Faculty of Horticulture, Chiba University:Japan Eco-science (Nikkan Kagaku) Co. Ltd.
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Satoh Takashi
Division of Molecular Hematology, Kitasato University Graduate School of Medical Sciences
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Nishiuchi Takumi
Division of Functional Genomics, Advanced Science Research Center, Kanazawa University
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Matsushita Teruo
Department of Food Science and Technology, National Fisheries University
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Kodama Hiroaki
Graduate School of Advanced Integration Science, Chiba University
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Naito Tomoaki
Department of Biochemistry and Integrative Medical Biology, Keio School of Medicine
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Miyamoto Hisashi
Miroku Co. Ltd.
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MIYAMOTO Hirokuni
Department of Biochemistry and Integrative Medical Biology, Keio School of Medicine
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