1P1-C19 MeMEプロセスを用いた人工毛細血管デバイスの開発

概要

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We propose a novel scaffold for tissue engineering, utilizing three-dimensional membrane microfluidic device we have previously developed. This scaffold consists of hydrogel and "artificial microcapillary device", which is a three-dimensional microfluidic device made of thin mesoporous biodegradable polymer membrane. The artificial microcapillary device exchanges gas and nutrients necessary for the cells inside the large scaffold. Here, we have successfully fabricated a prototype of artificial microcapillary device using MeME process. We have confirmed the size selective transfer between inside and outside of the microchannel using micro-beads of various sizes. We also investigated the biocompatibility of the device by culturing Human Umbilical Vascular Endothelial Cells (HUVEC) on the device. This result leads to the regeneration of large tissues and organs in vitro, which is impossible using conventional scaffolds.
一般社団法人日本機械学会の論文