F4-4 ナノメディシン・Bio-MEMS技術開発(F-4 安全・安心社会創生のための医工学技術開発)

概要

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In this paper, a novel method of platform for regenerative medicine are proposed and experimentally demonstrated. To realize a regenerative medicine, it is key issue to measure not only the cell-cell interactions and communications but the cell-tissue interactions. We have developed single-mask fabrication method for high aspect-ratio embedded micro-channels and high-density arrayed micro-orifices to measure the cell-cell communications for more than several thousand cells simultaneously. To stimuli the target cells and/or to bring foreign substances, such as genes and drugs, into the cells, we have also developed the high-efficiency low-voltage (typically 1.5V) electroporation method and demonstrated its efficiency.
社団法人日本機械学会の論文
2007-11-25