42 ミナミウシノシタ防御粘液中の魚毒性及び溶血性ステロイドN-アセチルグルコサミン配糖体

概要

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The sole Pardachirus pavoninus emits ichthyotoxic secretion from defensive cells lined at bases of its fins when disturbed. The secretion falls under the category of ichthyocrinotoxins which is presumed to work for the hosts as repellent against predatory fishes. The major hemolytic factor has been separated from the P. pavoninus secretion and found to be a mixture of steroid mono-glycosides, which are closely related to one another in terms of the chemical structure. The glycosides are lethal to Japanese killyfish at the concentration below 10 μg/mL and have comparable hemolytic activities to a commercial saponin on rabbit blood cell. Six major ichthyotoxins were isolated and named pavoninins-1, -2, -3, -4, -5, and-6. Their structures were elucidated to be 3, 4, 6, 7, 9, and 10 respectively by means of intensive ^1H nmr analyses and other spectroscopic studies, chemical modification, degradation, and correlation to one another.
天然有機化合物討論会の論文
1982-09-10